Aplication of Pamidronate (Bifosfonate) in patients suffering from Osteogenesis Imperfecta

Osteogenesis Imperfecta (O.I) groups diverse symptomology of a hereditary disease in which there is a collagen disorder, that is a present protein in connective tissue, especially in the bone.

As a consequence, there is bone fragility, frequent fractures caused by minimum trauma or even espontaneously, bone deformities and pain, and low height in most cases.

Most patients have blue sclera (the eye white portion), small, stained teeth, lowering of audition and muscle strength.

However, there is no a “healing” treatment for the disease until future genetics can achieve it; nowadays, it is posible to treat it with special medication to imporve the quality of the bone in order to avoid frequent fractures and another signs of the disease. When increasing the bone density, the patient is able to bear his own weight and able to practice sports activities, improving his quality of life.

At the Institute of Orthopaedics and Plastic Surgery, the treatment of O.I. is done by using Bifosfonates. This medication accumulates into the bone and make it more resistant..

Most used bifosfonate for treating O.I. is Pamidronate, intravenous injection and can be used in children and adults, but authors like Glorieux (Canada) has demonstrated that is more convenient to start as soon as possible, even in children less than 2 years old.

Starting with a 0.5 mgr/kg dosis of pamidronate dosis, an slow I.V. is injected for 3-4 hours during 3 days. Medical supervision during application. Cycles must be repeated every three months, at least for 1 or 2 years.

Pamidronate side effects are few: Mild fever, redness, swelling or pain at injection site, stomach pain, loss of appetite, nausea, constipation or initial increase in bone pain may occur. These effects are not present in most patients and they are controlled easily with medication.

It is recommended to take calcium (800-1000mg) and vitamin D (400 u) a day.

Thanks to Science and Medicine THE ETERNAL YOUTH DOES EXIST

The Facial rejuvenation is a very important tool for those that want to remain young despite of time.

The search for the eternal youth begins when the first wrinkles appears on the face. Men and women equally ask themselves what they should do to avoid the process of aging: Masks, solar filters, moisturizing cream? It is true, these are some of the basic options to keep a healthy skin and they are at reach of everybody. But unfortunately, they do not totally avoid the facial aging. Therefore, people goes to the plastic surgeon to look for another kind of action that can improve the face aspect.

According to the age of the person and the type of wrinkles shown, there are different options:

Botox:
Useful for frontal, brow, eye wrinkles, It allows a fresh appearance and free of wrinkles for six months.

Hyaluronic Acid:
It Is a non-surgical treatment for filling brow and nasogenian wrinkles. They have lasting results, even a year after its application.

Vasculight:
In patients over 35, collagen and elastic fibers are sought to be stimulated with high technology like this one, that permits to return the freshness and young skin appearance

CO2 Laser:
When wrinkles are very deep, peeling is required to be done with CO2 laser. These procedures remove the skin superficial layers, improving acne scars and superficial and intermediate wrinkles.

Anti-aging vaccine:
Swiss product made of sheep embryos and human placenta. It is the only one product that can keep the youth result through time, since it allows to keep functioning the young organism inside out. Its application should be started when 35 years old to guarantee an appearance of 35 when the person will be 45.

An ideal care

Most patients consult after they are 40, when the aging is evident. In these cases, the only option to rejuvenate is surgery or doing procedures such as blepharoplasty, minifacelift or total facelift.

The importance of keeping a young skin is explained in an adequate care since adolescence, a healthy diet of solar protection since childhood. This reduces damage caused by solar rays.

Fortunately, science and medical achievements offer more alternatives so that men and women look young at any age. What is important is to consult a certificate plastic surgeon by Colombian Plastic Surgery Association, in order to get good results.